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Aggregatibacter (Actinobacillus) actinomycetemcomitans is a Gram-negative coccobacillus of the Pasteurellaceae family. It is implicated in periodontitis, a common low-grade bacterial infection, but it can also cause non-oral infections. The main aim of this project was to identify and characterize in A. actinomycetemcomitans novel cell surface components bearing virulence potential that could contribute to systemic immunoinflammatory burden. We first established and evaluated a method for preparing homogeneous cell suspensions of autoaggregating clinical isolates of A. actinomycetemcomitans. The chosen method is based on a gradual dispersion of bacterial colonies into solution, which generated homogeneous suspensions without losing cell viability or fimbriation. When sera from two patients with A. actinomycetemcomitans-associated infec...
The background of the project is partly found in a long tradition within library and information science (LIS) of meta-analyses on the field, partly in a science studies discussion on research fields and their contextual relation to wider academia, fields of professional practices and professionalization processes. The general purpose of the project is to analyze the social and intellectual development and organization of LIS; and to investigate the impact of the close relation to the practice field, as well as the relation to the academic world in general. Based on the general purpose of the project and results and interpretations of the four articles attached to the thesis, three questions were stated for discussion in the thesis proper, concerning: the effects of a dual origin and LIS as a discipline, a field of research and a field...
In 2003, the Swedish Parliament adopted a national public health policy that included the domain - “A more health-promoting health service”. Strategies and tools are needed in the work to reorient health services. Personal health documents are documents concerning a person’s health, and are owned by the individual. Several studies that have evaluated such documents indicate that they could be of interest in health-promotion work. However, there is insufficient knowledge concerning personal health documents that target adolescents, and little is known about the feasibility of such documents in a Swedish cultural context. The concept of empowerment is gaining increased interest for health services, but the associations between empowerment, self-rated health and health behaviour are sparsely studied. The overall aim of the thesis is to ex...
Med FN:s konferens om miljö och utveckling i Rio de Janeiro 1992 fick handlingsprogrammet Agenda 21 och begreppet hållbar utveckling en enorm internationell uppmärksamhet. Samtidigt bröt Agenda 21 dokumentet mycket med tidigare insatser på miljö- och utvecklingsområdet i det att medborgarnas direkta deltagande i beslutsfattandet uppmuntrades. Tio år efter Rio hade 70 procent av landets kommuner antagit en lokal Agenda 21 i kommunfullmäktige och en folkrörelse hade startat där politiker, tjänstemän och eldsjälar involverade allmänheten i studiecirklar, direkta dialoger och övergripande kommunalt planeringsarbete. På detta sätt gjordes underifrånidealet till en demokratifråga där tjänstemän och politiker överlämnade delar av förvaltningsorganisationens maktutrymme till allmänheten. Under senare år finns dock en tendens som pekar på att a...
This bachelors thesis examines how av new musicfestival in Umea is communicated on the festivals website and how the communication is beeing percepted by people who have bought tickets to the festival and people who have chosen not to. The material is based on qualitative interviews with theese people and a discourse analysis of the website. The methods beeing used in this thesis are discourse analysis and qualitative interviews. The interviews focuses on two groups, people who have bought tickets to the festival and the ones who has not. The results of the analysis shows that the website uxufestival.se communicates the vision of a unique festival who brings people together. The people who have bought tickets and the people who haven't identify themselves with the targeted group. There's difference in the way that the two groups have p...
I denna studie har vi valt att undersöka vilka upplevelser av bemötande och stödinsatser mödrar med en utvecklingsstörning har i samband med deras föräldraskap. Att bli förälder innebär en utmaning för oss alla, men för föräldrar med en utvecklingsstörning kan föräldraskapet innebära svårigheter som gör att utmaningen blir svår att klara av. Forskning har dock visat att med rätt stöd kan föräldrarna bli tillräckligt bra föräldrar. Det finns en stor kunskapsbrist på området som resulterar i fördomar och en risk att föräldrarna inte får det stöd som de behöver. Vi har valt att göra en kvalitativ studie som bygger på intervjuer med tre mödrar som har en utvecklingsstörning i Umeå Kommun. Studien visade på både positiva och negativa upplevelser gällande bemötande och stödinsatser. Trots att mödrarnas berättelser skiljde sig åt, så delade m...
Background: Glioblastoma is the most common and aggressive type of glioma and associated with poor prognosis. Apart from ionizing radiation and some rare genetic disorders, few aetiological factors have been identified for primary brain tumours. Inverse associations to asthma and low IgG levels for varicella zoster virus have in previous studies indicated that the immune system may play a role in glioma development. Little is known about prognostic factors in glioma. Previous studies have shown an association between age, Karnofsky performance status, O6-methylguanine-DNA methyltransferase (MGMT) hypermethylation, and prognosis. Polymorphisms in different low penetrance genes have in some studies been associated with glioma prognosis. Material and methods: In paper I, we analysed IgG levels for four different viruses, Epstein-Barr viru...
Judgments that demand consideration of pieces of information in the environment occur repeatedly throughout our lives. One professional example is that of a physician that considers multiple symptoms to make a judgment about a patient’s disease. The scientific study of such, so called, multiple-cue judgments that involve multiple pieces of information (cues: e.g., symptoms) and continuous criterion (e.g., blood pressure) has been concerned with the statistical modelling of judgment data (see Brehmer, 1994; Cooksey, 1996; Hammond & Stewart, 2001). In this thesis behavioural experiments, cognitive modelling and brain imaging is used to investigate an adaptive division of labor between multiple memory representations in multiple-cue judgment. It is hypothesized that the additive, independent linear effect of each cue can be explicitly...
