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__Abstract__
The wild and the everyday point at once to twinned aspects of life and, in this article, to a technological imaginary drawing upon the use of the mobile internet in urban slums of India. The article responds to the rather untethered way, from the point of view of state regulation, in which the telecom market in India has devolved to include poor populations, stoking a repertoire of unconventional daily use of the internet by youth living in slums. This article serves to locate the ‘wild and everyday’ as a specific sociocultural space in relation to use of mobile Facebook among young populations invisible to mainstream research on internet and culture. While development, as conventionally understood, is not focused on purposive outcomes of digital leisure practice (romance, play, entertainment), we argue that online enga...
The aim of this study was to assess the cost-effectiveness, from a health care perspective, of adding rituximab to fludarabine and cyclophosphamide scheme (FCR versus FC) for treatment-naïve and refractory/relapsed Ukrainian patients with chronic lymphocytic leukemia. A decision-analytic Markov cohort model with three health states and 1-month cycle time was developed and run within a life time horizon. Data from two multinational, prospective, open-label Phase 3 studies were used to assess patients’ survival. While utilities were generalized from UK data, local resource utilization and disease-associated treatment, hospitalization, and side effect costs were applied. The alternative scenario was performed to assess the impact of lower life expectancy of the general population in Ukraine on the incremental cost-effectiveness ratio (IC...
BACKGROUND: Cardiovascular complications are the most important causes of
perioperative morbidity and mortality among patients undergoing major
vascular surgery. METHODS: We performed a randomized, multicenter trial to
assess the effect of perioperative blockade of beta-adrenergic receptors
on the incidence of death from cardiac causes and nonfatal myocardial
infarction within 30 days after major vascular surgery in patients at high
risk for these events. High-risk patients were identified by the presence
of both clinical risk factors and positive results on dobutamine
echocardiography. Eligible patients were randomly assigned to receive
standard perioperative care or standard care plus perioperative
beta-blockade with bisoprolol. RESULT...
OBJECTIVES: To determine the best approach for live donor nephrectomy to minimise discomfort to the donor and to provide good graft function.
DESIGN: Single blind, randomised controlled trial. SETTING: Two university medical centres, the Netherlands. PARTICIPANTS: 100 living kidney donors.
INTERVENTIONS: Participants were randomly assigned to either laparoscopic donor nephrectomy or to mini incision muscle splitting open donor nephrectomy. MAIN OUTCOME MEASURES: The primary outcome was physical fatigue using the multidimensional fatigue inventory 20 (MFI-20).
Secondary outcomes were physical function using the SF-36, hospital stay after surgery, pain, operating times, recipient graft function, and graft survival. RESULTS: Conversions did not occur. Compared with mini incision open donor nephrectomy, laparoscopic donor nephrectomy resul...
We identified, by homozygosity mapping, a novel locus on 10q21.3-q22.1 for
Goldberg-Shprintzen syndrome (GOSHS) in a consanguineous Moroccan family.
Phenotypic features of GOSHS in this inbred family included microcephaly
and mental retardation, which are both central nervous system defects, as
well as Hirschsprung disease, an enteric nervous system defect.
Furthermore, since bilateral generalized polymicogyria was diagnosed in
all patients in this family, this feature might also be considered a key
feature of the syndrome. We demonstrate that homozygous nonsense mutations
in KIAA1279 at 10q22.1, encoding a protein with two tetratrico peptide
repeats, underlie this syndromic form of Hirschsprung disease and
generalized polymicrogyria, establishing the importance of KIAA1279 in...
Arterial spin labeling (ASL) magnetic resonance imaging is increasingly used to quantify task-related brain activation. This study assessed functional ASL (fASL) using pseudo-continuous ASL (pCASL) product sequences from two vendors. By scanning healthy participants twice with each sequence while they performed a motor task, this study assessed functional ASL for 1) its sensitivity to detect task-related cerebral blood flow (CBF) changes, and 2) its reproducibility of resting CBF and absolute CBF changes (delta CBF) in the motor cortex. Whole-brain voxel-wise analyses showed that sensitivity for motor activation was sufficient with each sequence, and comparable between sequences. Reproducibility was assessed with within-subject coefficients of variation (wsCV) and intraclass correlation coefficients (ICC). Reproducibility of resting CB...
High rates of comorbidity between alcohol use disorder (AUD) and major depressive disorder (MDD) are reported. Preclinical models
examining effects of primary depression on secondary AUD are currently absent, preventing adequate testing of drug treatment. Here,
we combined social defeat-induced persistent stress (SDPS) and operant alcohol self-administration (SA) paradigms to assess causality
between these two neuropsychiatric disorders. We then exploited guanfacine, an FDA-approved adrenergic agent reported to reduce
drug craving in humans, against SDPS-induced modulation of operant alcohol SA. Wistar rats were socially defeated and isolated for a
period of X9 weeks, during which depression-like symptomatology (cognitive and social behavioral symptoms) was assessed.
Subsequently, animals were subjected to a 5-month operant alcoh...
Background: Physicians utilize different types of information to predict patient prognosis. For example: confronted with a new patient suffering from severe aortic stenosis (AS), the cardiologist considers not only the severity of the AS but also patient characteristics, medical history, and markers such as BNP. Intuitively, doctors adjust their prediction of prognosis over time, with the change in clinical status, aortic valve area and BNP at each outpatient clinic visit. With the help of novel statistical approaches to model outcomes, it is now possible to construct dynamic event prediction models, employing longitudinal data such as AVA and BNP, and mimicking the dynamic adjustment of prognosis as employed intuitively by cardiologists. We illustrate dynamic prediction of patient survival and freedom from intervention, using baseline...
