Commentary on Section 264 of ITAA 1936: commissioner may require information and evidence
Dabner, Justin
2007-01-01
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16 records were found.
In the last years, it has been reported that
bone marrow stromal cells (BMSC) are able to
differentiate towards a neuronal phenotype, in vitro as
well as in vivo, and consequently, the possible use of
these cells for the treatment of neurological diseases has
acquired enormous importance. The objective of this
review is to discuss the experimental findings that
suggested the utility of BMSC for the treatment of
paraplegia, and the possibilities of its clinical application
in patients. For this reason, we revise our previous
experimental findings about neuronal transdifferentiation
of BMSC, and the utility of local BMSC transplantation
in an experimental model of chronic paraplegia. Our
current experience supports that a neural
transdifferentiation of BMSC is possible after these
mesenchymal stem cells are transplanted into injured
spin...
Galerkin scheme; Purely integral conditions; Two-dimensional hyperbolic integro-differential equation;
The first barometers in the Americas were provided by the Royal Society of London in 1677 to correspondents in the Caribbean Island of Barbados. Colonel William Sharpe of Barbados was the first person in the Americas to make daily observations of the weather using a meteorological instrument (other than a wind vane) and made the first known measurements of barometric pressure within the circulation of a hurricane on 12 August 1680. His record provides new insight into the early history of the barometer and early perceptions of tropical weather, vindicates the hypothesis that the barometer would prove useful in detecting hurricanes, and contributes to Edmund Halley's understanding of the empirical distinctions between the Tropics and temperate zones. Sharpe's name and contributions, previously unknown to the meteorological community, ca...
A monoclonal antibody against the surface
marker IOT-10 of natural killer (NK) cells was used to
investigate the presence of these cells in a series of twenty
intracranial meningiomas. In al1 of these tumours, IOT-
10 positive NK cells were found in small numbers, mainly
distributed among the tumor cells. Two recurrent tumors
showed a relatively high number of immunostained cells.
The data obtained in the present study suggest that a NKcell-
mediated immunological response can occur in
meningioma tissue.
A technique for staining the nucleolar
organizer regions (NORs) in tumor cells applied to
smears from brain tumor biopsy specimens is described.
This technique provides a rapid intraoperative
evaluation of the proliferative activity in cerebral
neoplasms and is a valuable complement to hematoxylineosin
stained smears, supporting the critera of benignity
or malignancy in these tumors.
The presence of IOT-10-positive lymphocytes
among the tumor-infiltrating-lymphocyte (TIL)
population was studied in a series of 185 brain tumors.
In most of the tumors, IOT-10-positive lymphocytes
were identified, but generally they were scarce and
masked among the tumor cells, suggesting that NK-cells
exercise a poor participation in the tissular response
against brain tumors. Isolated tumor cells showing IOT-
10-positivity were found in low-grade astrocytomas,
neurinomas and medulloblastomas. IOT- 10-positivity on
both tumor neuropil and tumor cells was considered a
characteristic finding in oligodendrogliomas. The
number of IOT- 10-positive NK-cells in brain metastases
and in cerebellar hemangioblastomas was comparatively
greater than in other types of brain tumor. Since in brain
metastases, the presence of IOT-10-pos...
The purpose of this study is to evaluate, in an
experimental model of spinal cord injury (SCI), the
presence of apoptotic cell death after trauma and if early
administration of a single bolus of methylprednisolone
(MP) influences apoptosis in the zone of trauma and in
adjacent spinal cord segments. For this study, a total of
96 adult female Wistar rats were subjected to spinal
contusion at the T6-T8 level, producing immediate
paraplegia. Forty-eight animals (treated group) received
a single intraperitoneal injection of MP, at a dose of 30
mg/kg body weight, 10 minutes later. Cells undergoing
apoptosis were detected by means of
immunohistochemical labeling with the monoclonal
antibody Apostain (anti-ssDNA MAb F7-26), in the
injured spinal cord tissue, both in the zone of the lesion
and in the adjacent spinal segments (ros...
When a severe neurological lesion occurs as
a consequence of intracerebral bleeding, no effective
treatment for improving the outcome is currently
available. In the present study, intracerebral hemorrhage
(ICH) was induced by stereotactic injection of 0.5 U of
collagenase type IV in the striatum of adult Wistar rats,
and three days later, intralesional administration of
2x106 allogeneic bone marrow stromal cells (BMSC) in
saline (n:10), or saline only (n:10), was performed. In
the following 30 days, functional outcome was evaluated
in each animal by rotarod and the modified neurological
severity score (mNSS) test. Progressive and functional
improvement was observed in BMSC-transplanted rats
compared with controls, together with morphological
images suggesting that intracerebral administration of
BMSC increases endogenous neurogenesis a...
We present the irnmunohistochernical study
of 11 cases of intracranial cysts: two extraventricular
ependymal cysts, three colloid cysts of the third
ventricle, four extraventricular choroidal cysts and two
Rathke's cleft cysts. Antibodies against glial fibrillary
acidic protein (GFAP), cytokeratins (AE1, CKSD, AE3),
S-100 protein, epithelial membrane antigen (EMA),
vimentin, neuron specific enolase (NSE), neurofilaments
protein (NF) and prealbumin, were used. The epithelium
of choroidal cysts, showed strong immunoreactivity for
Prealbumin and cytokeratins, similar to the normal
choroid plexus epithelium. The ependymal cysts showed
epithelial immunoreactivity for GFAP and S-100, both
glial markers expressed by the normal ependymal
epithelium. On the contrary, the epithelial wall of colloid
cysts and Rathke's cleft cyst, e...
This paper documents a rare spell of severe weather in Spain that took place during the mid-nineteenth century when a tropical storm struck the southwest of the country on 29 October 1842. The use of a variety of independent documentary sources has provided unprecedented scope for the analysis of this event, allowing it to be set within its wider context, and for a judgement to be made on its tropical origin. The evidence suggests that this was similar, though stronger, to the more recent Hurricane Vince, which made landfall in Spain on 10 October 2005. This case study not only places Hurricane Vince, suggested at the time to have been unique, in its more proper long-term context, but it also demonstrates how documentary sources can improve our wider understanding of climate dynamics during historical times in the Atlantic basin.
