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Endometriosis is a debilitating disease that is diagnosed in 0.5-5% fertile and 25-40% of infertile women, but the underlying mechanisms involved in progression of the disease as well as the associated infertility are yet unclear. Research now shows evidence that the immune system has a pivotal role in endometriosis development as well as the related infertility. Among other immune cells, the T-helper lymphocytes accumulate in the normal endometrium during the mid- to late-secretory phase of the menstrual cycle and are considered essential for endometrial receptivity. The goal of this project was to 1) study the relationship between anti-inflammatory T-regulatory (Treg) and pro-inflammatory T-helper-17 (Th17) lymphocytes in the eutopic endometrium of patients with the primary complaint of infertility; 2) explore the involvement of inte...

male, and therefore to sustain spermatogenesis. There is a general lack of mechanistic insights on how particulate matter (or ultra fine particles) alter male fertility. A few studies showed that ultra fine particles (UFP) and some nanoparticles (manufactured particles in the same range of size as UFPs) are able to cross biological barriers such as the gut or the lung epithelium. After reaching the blood stream, these particles are distributed though the organism and eventually reach the testis and even cross the blood testis barrier. However, little is known about the possible targets. In the first part of this dissertation, I demonstrated that silver nanoparticles (which are present in an increasing number of commercial products), are toxic for spermatogonial stem cells by targeting glial cell-line derived neutrotrophic fact...

Bosques y silvicultura, Desarrollo urbano, Gestión de recursos naturales, Desarrollo proyectos de áreas verdes urbanas