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Research motivation: Bone tissue scaffolds offer a way forward in a strategy to change from tissue replacement to tissue regeneration. Bone tissue scaffolds are a combination of a physical construct, with clearly defined three-dimensional spatial properties, and biological cells. The microstructure of this construct is the bridge between the physicochemical properties of the scaffold and the cellular processes responsible for tissue regeneration. Gap statement: A formal design methodology has yet to be applied for the design of bone tissue scaffolds Aims and objectives: The aim of this research thesis is to select and apply design methods to the design of bone tissue scaffolds. The objectives are: 1. Review the current state of the art in design theory and methodologies for successful applications of design methods 2. Identify which de...