Projecto e património edificado em São Paulo. Três casos como práticas de mudança.
Carolina Miguel dos Santos Barreiros
2013-11-06
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36,350 records were found.
Enhanced motivation to take drugs is a central characteristic of addiction, yet the neural underpinning of this maladaptive behavior is still largely unknown. Here, we report a D1-like dopamine receptor (DRD1)-mediated long-term potentiation of GABAA-IPSCs (D1-LTPGABA) in the oval bed nucleus of the stria terminalis that was positively correlated with motivation to self-administer cocaine in rats. Likewise, in vivo intra-oval bed nucleus of the stria terminalis DRD1 pharmacological blockade reduced lever pressing for cocaine more effectively in rats showing enhanced motivation toward cocaine. D1-LTPGABA resulted from enhanced function and expression of G-protein-independent DRD1 coupled to c-Src tyrosine kinases and required local release of neurotensin. There was no D1-LTPGABA in rats that self-administered sucrose, in those with limi...
The bed nucleus of the stria terminalis (BNST) exerts a coordinated modulation of the psychoneuroendocrine responses to stress. However, how acute stress impacts on BNST in vivo plasticity is a crucial question that still remains unanswered. Here, neurons from the anterior portion of the BNST (aBNST) were recorded in vivo during and after stimulation of their medial prefrontal cortical (mPFC) afferents. In C57BL/6N mice, a 1 h restraint stress induced a switch from long-term depression (LTD) to long-term potentiation (LTP) in the aBNST after a 10 Hz mPFC stimulation. This switch was independent from glucocorticoid receptor stimulation. Because the endocannabinoid system regulates aBNST activity, we next examined the role of cannabinoid type-1 receptors (CB1-Rs) in these changes. Mutant mice lacking CB1-Rs (CB1(-/-) mice) displayed a ma...
The bed nucleus of the stria terminalis (BST) is a cluster of nuclei within the extended amygdala, a forebrain macrostructure with extensive projection to motor nuclei of the hindbrain. The subnuclei of the BST coordinate autonomic, neuroendocrine, and somato-motor functions and receive robust neuromodulatory monoaminergic afferents, including 5-HT-, noradrenaline (NA)-, and dopamine (DA)-containing terminals. In contrast to 5-HT and NA, little is known about how DA modulates neuronal activity or synaptic transmission in the BST. DA-containing afferents to the BST originate in the ventral tegmental area, the periaqueducal gray, and the retrorubral field. They form a fairly diffuse input to the dorsolateral BST with dense terminal fields in the oval (ovBST) and juxtacapsular (jxBST) nuclei. The efferent-afferent connectivity of the BST ...
Understanding the genetic bases underlying heterosis is a major issue in maize (Zea mays L.). We extended the North Carolina design III (NCIII) by using three populations of recombinant inbred lines derived from three parental lines belonging to different heterotic pools, crossed with each parental line to obtain nine families of hybrids. A total of 1253 hybrids were evaluated for grain moisture, silking date, plant height, and grain yield. Quantitative trait loci (QTL) mapping was carried out on the six families obtained from crosses to parental lines following the "classical" NCIII method and with a multiparental connected model on the global design, adding the three families obtained from crosses to the nonparental line. Results of the QTL detection highlighted that most of the QTL detected for grain yield displayed apparent overdom...
A number of global land surface models simulate photosynthesis, respiration, and
disturbance, important flows in the carbon cycle that are widely tested against flux towers
and CO2 concentration gradients. The resulting forest biomass is examined in this
paper for its resemblance to realistic stands, which are characterized using allometric
theory. The simulated biomass pools largely do not conform to widely observed allometry,
particularly for young stands. The best performing models had an explicit treatment of
stand‐thinning processes, which brought the slope of the allometry of these models closer
to observations. Additionally, models that had relatively shorter wood turnover times
performed were generally closer to observed allometries. The discrepancy between the
pool distribution between models and data suggests estimates of NEE...
Objectif L’ibogaïne, alcaloïde extrait de Tabernanthe iboga, est depuis longtemps utilisé en Afrique de l’Ouest à des fins rituelles ou de médication. Depuis quelques années, cette substance est proposée pour lutter contre les addictions, en particulier à l’alcool et aux opiacés [1]. Nous présentons les données médico-légales, cliniques et analytiques concernant une femme de 30 ans dépendante à l’héroïne, retrouvée décédée, et pouvant avoir consommé une poudre achetée via Internet étiquetée « Iboga du Gabon ». Nous présentons également les données relatives à l’identification et à l’analyse de cette poudre, e les corrélations avec les conclusions de l’autopsie. Méthodes La poudre et les prélèvements biologiques (sang périphérique et bile) ont été extraits et analysés selon une méthode de screening par un couplage LC-MS en haute résolut...
